Meru Nukumi gained prominence as an exclusive model for Shogakukan's CanCam magazine. In July 2022, she made her debut as a leading actress in the film My Boyfriend in Orange; her performance earned her a Newcomer of the Year award at the 46th Japan Academy Film Awards. Further demonstrating her versatility, she voices the character of Anna Scervino in the upcoming anime film My Hero Academia: You’re Next.